Journal
NANO LETTERS
Volume 14, Issue 9, Pages 5110-5117Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl501839q
Keywords
Single-walled carbon nanotubes; primary glia; autophagy; Alzheimers disease
Categories
Funding
- Chinese Natural Science Foundation [81171455]
- National Natural Science Foundation of China [31225009]
- National Key Basic Research Program of China [2009CB930200]
- Chinese Academy of Sciences (CAS) [07165111ZX]
- CAS Knowledge Innovation Program
- State High-Tech Development Plan [2012AA020804, SS2014AA020708]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA09030301]
- U.S. National Institute on Aging [P01AG017617]
- Takeda Pharmaceuticals, Ltd
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Defective autophagy in Alzheimer's disease (AD) promotes disease progression in diverse ways. Here, we demonstrate impaired autophagy flux in primary glial cells derived from CRND8 mice that overexpress mutant amyloid precursor protein (APP). Functionalized single-walled carbon nanotubes (SWNT) restored normal autophagy by reversing abnormal activation of mTOR signaling and deficits in lysosomal proteolysis, thereby facilitating elimination of autophagic substrates. These findings suggest SWNT as a novel neuroprotective approach to AD therapy.
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