Journal
NANO LETTERS
Volume 14, Issue 7, Pages 3908-3913Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl501166m
Keywords
Nanoparticle assemblies; chiroplasmonic properties; core-shell deposition; amplification; biosensing
Categories
Funding
- MOST [2012BAC01B07]
- NSFC [21101079, 21371081, 21301073]
- MOE [NCET-12-0879]
- Center for Solar and Thermal Energy Conversion, an Energy Frontier Research Center - U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-SC0000957]
- ARO MURI [W911NF-12-1-0407]
- NSF [CBET 1036672]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1403777] Funding Source: National Science Foundation
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DNA-bridged pairs of seemingly spherical metallic nanoparticles (NPs) have chiral geometry due to the nonideal oblong shape of the particles and scissor-like conformation. Here we demonstrate that deposition of gold and silver shells around the NP heterodimers enables spectral modulation of their chiroplasmonic bands in 400-600 nm region and results in significantly enhanced optical activity with g-factors reaching 1.21 x 10(-2). The multimetal heterodimers optimized for coupling with the spin angular momentum of incident photons enable polymerase chain reaction (PCR)-based DNA detection at the zeptomolar level. This significant improvement in the sensitivity of detection is attributed to improvement of base pairing in the presence of NPs, low background for chiroplasmonic detection protocol, and enhancement of photon-plasmon coupling for light with helicity matching that of the twisted geometry of the heterodimers.
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