Journal
NANO LETTERS
Volume 14, Issue 10, Pages 5761-5765Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl5026419
Keywords
Enzyme; metal-organic framework; nanomaterials; biocatalysis
Categories
Funding
- National High Technology Research and Development Program (863 Program) of China [2014AA020507]
- National Natural Science Foundation of China [21036003, 21206082]
- Tsinghua University Initiative Scientific Research Program [20131089191]
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Protein molecules were directly embedded in metal-organic frameworks (MOFs) by a coprecipitation method. The protein molecules majorly embedded on the surface region of MOFs display high biological activities. As a demonstration of the power of such materials, the resulting Cyt c embedded in ZIF-8 showed a 10-fold increase in peroxidase activity compared to free Cyt c in solution and thus gave convenient, fast, and highly sensitive detection of trace amounts of explosive organic peroxides in solution.
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