Journal
NANO LETTERS
Volume 14, Issue 5, Pages 2242-2250Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl4046685
Keywords
Protein analysis; electrode nanogap; dielectrophoresis; conductance; surface-enhanced Raman spectroscopy (SERS)
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Funding
- AS Nano Program
- AS Integrated Thematic Project [AS-103-TP-A01]
- National Science Council, Taiwan [102-2112-M-001-005-MY3, 103-2923-M-001-007-MY3]
- Asian Office for Aerospace Research and Development [FA2386-12-1-4002]
- Max-Plack-Institut fur Eisenforschung GmbH
- Incentive Fund Program of Costa Rica's National Council for Science and Technology Research-(CONICIT)
- Ministry of Science and Technology (MICIT)
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We report a versatile analysis platform, based on a set of nanogap electrodes, for the manipulation and sensing of biomolecules, as demonstrated here for low-copy number protein detection. An array of Ti nanogap electrode with sub-10 nm gap size function as templates for alternating current dielectrophoresis-based molecular trapping, hot spots for surface-enhanced Raman spectroscopy as well as electronic measurements, and fluorescence imaging. During molecular trapping, recorded Raman spectra, conductance measurements across the nanogaps, and fluorescence imaging show unambiguously the presence and characteristics of the trapped proteins. Our platform opens up a simple way for multifunctional low-concentration heterogeneous sample analysis without the need for target preconcentration.
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