Journal
NANO LETTERS
Volume 15, Issue 1, Pages 603-609Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl504079q
Keywords
Self-assembly; biomaterials; DNA nanotechnology; extracellular matrix; DNA-peptide; neural stem cells
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Funding
- Biomaterials Research Partnerships - National Institutes of Health/National Institute of Biomedical Imaging And Bioengineering Award [5RO1EB003806-09]
- TIN Postdoctoral Fellowship
- Northwestern International Institute for Nanotechnology
- NIH Ruth L. Kirschstein NRSA postdoctoral fellowship [1F32NS077728-01A1]
- EMBO Long-Term Postdoctoral Fellowship [ALTF 233-2012]
- Craig H. Neilsen Foundation postdoctoral grant
- Royal Thai Government
- NU Office for Research
- Cancer Center Support Grant [NCI CA060553]
- NATIONAL CANCER INSTITUTE [P30CA060553] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB003806] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [F32NS077728] Funding Source: NIH RePORTER
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We report the construction of DNA nanotubes covalently functionalized with the cell adhesion peptide RGDS as a bioactive substrate for neural stem cell differentiation. Alteration of the Watson-Crick base pairing program that builds the nanostructures allowed us to probe independently the effect of nanotube architecture and peptide bioactivity on stem cell differentiation. We found that both factors instruct synergistically the preferential differentiation of the cells into neurons rather than astrocytes.
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