Journal
NANO LETTERS
Volume 15, Issue 1, Pages 96-102Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl504123r
Keywords
NIR II; SWIR; second near-infrared; rare-earth; imaging; X-ray luminescence
Categories
Funding
- NIBIB [1R01 EB016777]
- NCI [1R01 CA133474]
- U.S. Department of Defense [W81XWH-11-1-0087]
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Shortwave infrared (SWIR or NIR-II) light provides significant advantages for imaging biological structures due to reduced autofluorescence and photon scattering. Here, we report on the development of rare-earth nanoprobes that exhibit SWIR luminescence following X-ray irradiation. We demonstrate the ability of X-ray-induced SWIR luminescence (X-IR) to monitor biodistribution and map lymphatic drainage. Our results indicate X-IR imaging is a promising new modality for preclinical applications and has potential for dual-modality molecular disease imaging.
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