Journal
NANO LETTERS
Volume 14, Issue 6, Pages 3563-3569Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl5012036
Keywords
Single cell; graphene; optical sensor; cancer; polarization-dependent absorption
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Funding
- Chinese National Key Basic Research Special Fund [2011CB922003]
- Natural Science Foundation of China [11174159, 11374164, 11204142]
- Natural Science Foundation of Tianjin [13JCYBJC16300]
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On the basis of the polarization-dependent absorption of graphene under total internal reflection, we designed a graphene-based optical refractive index sensor with high resolution of 1.7 x 10(-8) and sensitivity of 4.3 x 10(7) mV/RIU, as well as an extensive dynamic range. This highly sensitive graphene optical sensor enables label-free, live-cell, and highly accurate detection of a small quantity of cancer cells among normal cells at the single-cell level and the simultaneous detection and distinction of two cell lines without separation. It provides an accurate statistical distribution of normal and cancer cells with fewer cells. This facile and highly sensitive sensing refractive index may expand the practical applications of the biosensor.
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