Journal
NANO LETTERS
Volume 14, Issue 8, Pages 4887-4894Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl502338y
Keywords
Single-walled carbon nanotube; nitric oxide; sensor; photoluminescence
Categories
Funding
- National Science Foundation
- DOE CSGF program (DOE) [DE-FG02-97ER25308]
- National Institute of General Medical Sciences [T32 GM 65841, T32 5T32CA148073]
- NIH [HL70567, CA150190]
- DPU-ILTEM
- Department of Defense (DoD) through the National Defense Science & Engineering Graduate Fellowship (NDSEG) program
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Fluorescent nanosensor probes have suffered from limited molecular recognition and a dearth of strategies for spatial-temporal operation in cell culture. In this work, we spatially imaged the dynamics of nitric oxide (NO) signaling, important in numerous pathologies and physiological functions, using intracellular near-infrared fluorescent single-walled carbon nanotubes. The observed spatial-temporal NO signaling gradients clarify and refine the existing paradigm of NO signaling based on averaged local concentrations. This work enables the study of transient intracellular phenomena associated with signaling and therapeutics.
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