Journal
NANO LETTERS
Volume 14, Issue 2, Pages 1049-1055Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl404727m
Keywords
Cell membrane; nanotubes; cell interaction; microtubule; filopodia; molecular dynamics
Categories
Funding
- National Science Foundation under INSPIRE: Computational Design for the Safe Development of High-Aspect-Ratio Nanomaterials [GBET-1344097, CMMI-1028530]
- National Natural Science Foundation of China [11272327, 11023001]
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1028530] Funding Source: National Science Foundation
Ask authors/readers for more resources
Understanding cell interaction with one-dimensional nanomaterials, including nanotubes, nanowires, nanofibers, filamentous bacteria, and certain nanoparticle chains, has fundamental importance to many applications such as biomedical diagnostics, therapeutics, and nanotoxicity. Here we show that cell uptake of one-dimensional nanomaterials via receptor-mediated endocytosis is dominated by a single dimensionless parameter that scales with the membrane tension and radius of the nanomaterial and inversely with the membrane bending stiffness. It is shown that as cell membrane internalizes one-dimensional nanomaterials the uptake follows a near-perpendicular entry mode at small membrane tension but it switches to a near-parallel interaction mode at large membrane tension.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available