Journal
NANO LETTERS
Volume 13, Issue 7, Pages 3248-3255Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl401376w
Keywords
Nanoghosts; drug delivery; mesenchymal stem cells; cancer targeted therapy
Categories
Funding
- The Israeli Science Foundation (ISF) [2015103]
- Russell Berrie Nanotechnology Institute, Technion - IIT
- Ed Sattel Foundation
- Bert Richardson Foundation
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The ultimate goal in cancer therapy is achieving selective targeting of cancer cells. We report a novel delivery platform, based on nanoghosts (NGs) produced from the membranes of mesenchymal stem cells (MSCs). Encompassing MSC surface molecules, the MSC-NGs retained MSC-specific in vitro and in vivo tumor targeting capabilities and were cleared from blood-filtering organs. MSC-NGs were found to be biocompatible. Systemic administration of drug loaded MSC-NGs demonstrated 80% inhibition of human prostate cancer.
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