Journal
NANO LETTERS
Volume 14, Issue 1, Pages 83-88Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl4032549
Keywords
Nanoparticles; nanobio interactions; cell migration; microtubules; cell traction force
Categories
Funding
- Ministry of Education [R-279-000-350-112, R279-000-376-112]
- Faculty of Engineering Strategic Research Fund [R-397-000-136-112]
- Lee Kuan Yew Postdoctoral Fellowship
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Nanoparticles can have profound effects on cell biology. Here, we show that after TiO2, SiO2, and hydroxyapatite nanoparticles treatment, TR146 epithelial cell sheet displayed slower migration. Cells after exposure to the nanoparticles showed increased cell contractility with significantly impaired wound healing capability however without any apparent cytotoxicity. We showed the mechanism is through nanoparticle-mediated massive disruption of the intracellular microtubule assembly, thereby triggering a positive feedback that promoted stronger substrate adhesions thus leading to limited cell motility.
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