Journal
NANO LETTERS
Volume 13, Issue 10, Pages 4632-4641Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl401658c
Keywords
Array comparative genomic hybridization analysis (aCGH); carcinogenesis; chromosome aberration; genome-wide; HOXD family; multiple-walled carbon nanotubes (MWCNTs)
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Funding
- National Science Council [NSC101-2325-B002-047]
- National Taiwan University Cutting-Edge Steering Research Project [NTU CESRP-10R71602C2, 100R705057]
- Academia Sinica [AS- 100-TP-AB2]
- National Taiwan University Center of Integrated Core Facilities for Functional Genomics and Microarray Core Facility
- [F670-B8F1-1351144FA-2BCA]
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Multiple-walled carbon nanotubes (MWCNTs) may cause carcinogenesis. We found that long-term exposure to MWCNTs can induce irreversible oncogenic transformation of human bronchial epithelial cells and tumorigenicity in vivo. A genome-wide array-comparative genomic hybridization (aCGH) analysis revealed global chromosomal aberration in MWCNTs-treated clones, predominantly a: chromosome 2q31-32, where the potential oncogenes HOXD9 and HOXD13 are located. Functional assays confirmed that this variatim can modulate oncogenic signaling and plays a part in MWCNTs-induced tumorigenesis, suggesting that MWCNTs are carcinogens that act by altering genomic,stability and oncogenic copy numbers.
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