Journal
NANO LETTERS
Volume 13, Issue 9, Pages 4294-4298Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl402054w
Keywords
Quantum dots; CuInSe2; CuInS2; near-infrared; in vivo imaging; bioimaging; photoluminescence
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Funding
- Robert A. Welch Foundation [F-1464, F-1767]
- Gates Foundation Grand Challenges
- National Institutes of Health [R01 CA132032]
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Zinc sulfide-coated copper indium sulfur selenide (CuInSexS2-x/ZnS core/shell) nanocrystals were synthesized with size-tunable red to near-infrared (NIR) fluorescence with high quantum yield (40%) in water. These nanocrystals were tested as an imaging agent to track a microparticle-based oral vaccine administered to mice. Poly(lactic-co-glycolic acid) (PLGA) microparticle-encapsulated CuInSexSe2-x/ZnS quantum dots were orally administered to mice and were found to provide a distinct visible fluorescent marker in the gastrointestinal tract of living mice.
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