Journal
NANO LETTERS
Volume 12, Issue 10, Pages 5304-5310Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl302638g
Keywords
PRINT; nanoparticle; PEGylation; protein adsorption; macrophage association; pharmacokinetics
Categories
Funding
- Liquidia Technologies
- Carolina Center for Cancer Nanotechnology Excellence [U54CA151652]
- University Cancer Research Fund
Ask authors/readers for more resources
In this account, we varied PEGylation density on the surface of hydrogel PRINT nanoparticles and systematically observed the effects on protein adsorption, macrophage uptake, and circulation time. Interestingly, the density of PEGylation necessary to promote a long-circulating particle was dramatically less than what has been previously reported. Overall, our methodology provides a rapid screening technique to predict particle behavior in vivo and our results deliver further insight to what PEG density is necessary to facilitate long-circulation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available