Journal
NANO LETTERS
Volume 12, Issue 9, Pages 4830-4837Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl302273p
Keywords
Carbon nanotubes; cell microvesicles; bionano-interactions; environmental; health and safety issue
Categories
Funding
- ANR P2N [2010-NANO-008-04]
- Region Ile de France [E539]
- CNRS
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The fate of carbon nanotubes in the organism is still controversial. Here, we propose a statistical high-throughput imaging method to localize and quantify functionalized multiwalled carbon nanotubes in cells. We give the first experimental evidence of an intercellular translocation of carbon nanotubes. This stress-induced longitudinal transfer of nanomaterials is mediated by cell-released microvesicles known as vectors for intercellular communication. This finding raises new critical issues for nanotoxicology, since carbon nanotubes could be disseminated by circulating extracellular cell-released vesicles and visiting several cells in the course of their passage into the organism.
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