Journal
NANO LETTERS
Volume 12, Issue 7, Pages 3846-3850Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl301857p
Keywords
Atomic force microscopy; molecular resolution; DNA; nanoscale cantilevers; frequency and phase modulation
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Funding
- UK Biotechnology and Biological Sciences Research Council [BB/G011729/1]
- Biotechnology and Biological Sciences Research Council [BB/G011729/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [955756] Funding Source: researchfish
- BBSRC [BB/G011729/1] Funding Source: UKRI
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Structural variability and flexibility are crucial factors for biomolecular function. Here we have reduced the invasiness and enhanced the spatial resolution of atomic force microscopy (AFM) to visualize, for the first time, different structural conformations of the two polynucleotide strands in the DNA double helix, for single molecules under near-physiological conditions. This is achieved by identifying and tracking the anomalous resonance behavior of nanoscale AFM cantilevers in the immediate vicinity of the sample.
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