Journal
NANO LETTERS
Volume 12, Issue 7, Pages 3369-3377Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl204175t
Keywords
Single-walled carbon nanotubes; quantum dots; nanoparticle geometry; cancer; intravital microscopy; extravasation
Categories
Funding
- NIH R25T postdoctoral training grant
- K99/R00 Award [NCI K99 CA160764]
- [NCI U54 CA119367]
- [NCI ICMIC P50 CA114747]
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Delivery is one of the most critical obstacles confronting nanoparticle use in cancer diagnosis and therapy. For most oncological applications, nanoparticles must extravasate in order to reach tumor cells and perform their designated task. However, little understanding exists regarding the effect of nanoparticle shape on extravasation. Herein we use real-time intravital microscopic imaging to meticulously examine how two different nanoparticles behave across three different murine tumor models. The study quantitatively demonstrates that high-aspect ratio single-walled carbon nanotubes (SWNTs) display extravasational behavior surprisingly different from, and counterintuitive to, spherical nanoparticles although the nanoparticles have similar surface coatings, area, and charge. This work quantitatively indicates that nanoscale extravasational competence is highly dependent on nanoparticle geometry and is heterogeneous.
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