Journal
NANO LETTERS
Volume 12, Issue 3, Pages 1722-1728Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl300372a
Keywords
Nanopore; gamma PNA; sequence detection; molecular diagnostics; single-molecule; genotyping
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Funding
- Harvard's Center for Nanoscale Systems (CNS)
- National Institutes of Health [R01 HG-005871]
- National Science Foundation [PHY-0646637, CHE-1012467]
- DSF Charitable Foundation
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1012467] Funding Source: National Science Foundation
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A new single-molecule approach for rapid and purely electronic discrimination among similar genes is presented. Combining solid-state nanopores and gamma-modified synthetic peptide nucleic acid probes, we accurately barcode genes by counting the number of probes attached to each gene and measuring their relative spacing. We illustrate our method by sensing individual genes from two highly similar human immunodeficiency virus subtypes, demonstrating feasibility of a novel, single-molecule diagnostic platform for rapid pathogen classification.
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