Journal
NANO LETTERS
Volume 12, Issue 6, Pages 3127-3131Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl3010308
Keywords
Nanoparticle; nanomedicine; iron oxide; magnetic resonance imaging contrast agent; colloidal stability
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Funding
- National Research Foundation (NRF) of Korea through Strategic Research [2010-0029138]
- Global Research Laboratory [2011-0021628]
- World Class University [R31-10013]
- Ministry for Health, Welfare, and Family Affairs [A112028]
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The theoretically predicted maximum r(2) relaxivity of iron oxide nanoparticles was achieved by optimizing the overall size of ferrimagnetic iron oxide nanocubes. Uniform-sized iron oxide nanocubes with an edge length of 22 nm, encapsulated with PEG-phospholipids (WFION), exhibited high colloidal stability in aqueous media. In addition, WFIONs are biocompatible and did not affect cell viability at concentrations up to 0.75 mg Fe/ml. Owing to the enhanced colloidal stability and the high r(2) relaxivity (761 mM(-1) s(-1)), it was possible to successfully perform in vivo MR imaging of tumors by intravenous injection of 22-nm-sized WFIONs, using a clinical 3-T MR scanner.
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