4.8 Article

Reconfigurable DNA Origami to Generate Quasifractal Patterns

Journal

NANO LETTERS
Volume 12, Issue 6, Pages 3290-3295

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/nl301399z

Keywords

Dynamic DNA nanotechnology; strand displacement; reconfiguration; fractal

Funding

  1. ONR
  2. NSF
  3. ARO
  4. DOE
  5. NIH
  6. Sloan Research Foundation
  7. NSFC [21028005]
  8. Wong Kwan Cheng education foundation
  9. Direct For Computer & Info Scie & Enginr
  10. Division of Computing and Communication Foundations [0829685] Funding Source: National Science Foundation
  11. Direct For Mathematical & Physical Scien
  12. Division Of Materials Research [1104373] Funding Source: National Science Foundation

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The specificity of Watson Crick base pairing, unique mechanical properties of DNA, and intrinsic stability of DNA double helices makes DNA an ideal material for the construction of dynamic nanodevices. Rationally designed strand displacement reactions can be used to produce dynamic reconfiguration of DNA nanostructures postassembly. Here we describe a 'fold-release-fold' strategy of multiple strand displacement and hybridization reactions to reconfigure a simple DNA origami structure into a complex, quasifractal pattern, demonstrating a complex transformation of DNA nanoarchitectures.

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