Journal
NANO LETTERS
Volume 12, Issue 12, Pages 6480-6484Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl304063f
Keywords
Nanochannel; nanoconfinement; biopolymer; epigenetics
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Funding
- US National Institutes of Health [HG004653-03]
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This paper describes a novel nanofluidic phenomenon where untethered DNA and chromatin are linearized by rapidly narrowing an elastomeric nanochannel filled with solutions of the biopolymers. This nanoscale squeezing procedure generates hydrodynamic flows while also confining the biopolymers into smaller and smaller volumes. The unique features of this technique enable full linearization then trapping of biopolyrners such as DNA. The versatility of the method is also demonstrated by analysis of chromatin stretchability and mapping of histone states using single strands of chromatin.
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