Journal
NANO LETTERS
Volume 12, Issue 10, Pages 5082-5090Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl301714x
Keywords
Graphene; human olfactory receptor; flexible sensor; bioelectronic sensor; plasma treatment; odorants
Categories
Funding
- National Research Foundation of Korea (NRF) [2011-0017125, 2011-0000331, 2011K000682]
- World Class University (WCU) program through NRF
- Ministry of Education, Science and Technology (MEST) [R31-10013]
- National Research Foundation of Korea [2009-0080242, 2010-50232, R31-2012-000-10013-0, 2011-0017125] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
Rapid and precise discrimination of various odorants is vital to fabricating enhanced sensing devices in the fields of disease diagnostics, food safety, and environmental monitoring. Here, we demonstrate an ultrasensitive and flexible field-effect transistor (FET) olfactory system, namely, a bioelectronic nose (B-nose), based on plasma-treated bilayer graphene conjugated with an olfactory receptor. The stable p-and n-type behaviors from modified bilayer graphene (MBLG) took place after controlled oxygen and ammonia plasma treatments. It was integrated with human olfactory receptors 2AG1 (hOR2AG1: OR), leading to the formation of the liquid-ion gated FET-type platform. ORs bind to the particular odorant amyl butyrate (AB), and their interactions are specific and selective. The B-noses behave as flexible and transparent sensing devices and can recognize a target odorant with single-carbon-atom resolution. The B-noses are ultrasensitive and highly selective toward AB. The minimum detection limit (MDL) is as low as 0.04 fM (10(-15); signal-to-noise: 4.2), and the equilibrium constants of OR-oxygen plasma-treated graphene (OR-OG) and ammonia plasma-treated graphene (-NG) are ca. 3.44 X 10(14) and 1.47 X 10(14) M-1, respectively. Additionally, the B-noses have long-term stability and excellent mechanical bending durability in flexible systems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available