Journal
NANO LETTERS
Volume 11, Issue 10, Pages 4480-4484Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl202909s
Keywords
Protein-nanoparticle interaction; protein structure; protein stability; circular dichroism; synchrotron radiation
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Funding
- European Community [226716]
- Diamond Light Source
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We measure the structural and stability changes of proteins at nanomolar concentration upon interaction with nanoparticles. Using synchrotron radiation circular dichroism (SRCD), we measure a decrease of 6 degrees C in the thermal unfolding of human serum albumin upon interaction with silver nanoparticles while this does not happen with gold. The use of SRCD allows measuring critical parameters on protein-nanoparticle interactions, and it will provide experimental data on the relative stability of key biological proteins for nanotoxicology.
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