Journal
NANO LETTERS
Volume 12, Issue 1, Pages 396-401Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl203717q
Keywords
Nanomachines; microengines; lectin; E. coli isolation; theranostics; drug delivery; biodetection; complex samples
Categories
Funding
- National Science Foundation [CBET 0853375]
- National Institutes of Health [U01 AI075565]
- NATO [SfP 983807]
- Sandia National Laboratories
- Programa Becas Complutense del Amo
- Government of Catalonia
- ICREA Funding Source: Custom
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0853375] Funding Source: National Science Foundation
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New template-based self-propelled gold/nickel/polyaniline/platinum (Au/Ni/PANI/Pt) microtubular engines, functionafized with the Concanavalin A (ConA) lectin bioreceptor, are shown to be extremely useful for the rapid, real-time isolation of Escherichia coli (E. coli) bacteria from fuel-enhanced environmental, food, and clinical samples. These multifunctional microtube engines combine the selective capture of E. coli with the uptake of polymeric drug-carrier particles to provide an attractive motion-based theranostics strategy. Triggered release of the captured bacteria is demonstrated by movement through a low-pH glycine-based dissociation solution. The smaller size of the new polymer-metal microengines offers convenient, direct, and label-free optical visualization of the captured bacteria and discrimination against nontarget cells.
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