4.8 Article

DNA Tunneling Detector Embedded in a Nanopore

Journal

NANO LETTERS
Volume 11, Issue 1, Pages 279-285

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/nl103873a

Keywords

Nanopore sequencing; tunneling gap; DNA sequencing; label-free detection

Funding

  1. Wellcome Trust
  2. Corrigan Foundation
  3. Engineering and Physical Sciences Research Council [EP/H046593/1] Funding Source: researchfish
  4. EPSRC [EP/H046593/1] Funding Source: UKRI

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We report on the fabrication and characterization of a DNA nanopore detector with integrated tunneling electrodes. Functional tunneling devices were identified by tunneling spectroscopy in different solvents and then used in proof-of-principle experiments demonstrating, for the first time, concurrent tunneling detection and ionic current detection of DNA molecules in a nanopore platform. This is an important step toward ultrafast DNA sequencing by tunneling.

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