Journal
NANO LETTERS
Volume 11, Issue 10, Pages 4319-4323Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl202386p
Keywords
Graphene; electron microscopy; cryo-EM; crystallography
Categories
Funding
- NSF [0969106]
- Office of Naval Research
- Swiss initiative for Systems Biology (SystemsX.ch) [CINA]
- Swiss National Science Foundation (NCCR TransCure, NCCR Structural Biology, and NCCR Nano)
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [0969106] Funding Source: National Science Foundation
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Graphene represents the first practical realization of crystalline supports in biological transmission electron microscopy (TEM) since their introduction over 30 years ago. The high transparency, minimal inelastic cross-section, and electrical conductivity of graphene are highly desirable characteristics for a TEM support. However, without a suitable method for rendering graphene supports, hydrophilic applications are limited. This work describes the in situ functionalization of graphene with minimal structural degradation, rendering TEM supports sufficiently hydrophilic for the mounting of biological samples.
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