Journal
NANO LETTERS
Volume 12, Issue 1, Pages 420-423Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl203736u
Keywords
Cantilever array sensors; Escherichia coli; glycomics; biosensors; nanomechanics
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Funding
- DFG [HE5162/1-1]
- excellence cluster Nanosystems Initiative Munich
- Walter-Meissner Institute of the Bavarian academy of sciences and humanities
- Center for Nanoscience
- Elite Network of Bavaria
- Max-Planck Society
- Korber Prize for European Sciences
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Carbohydrate-based sensors, that specifically detect sugar binding molecules or cells, are increasingly important in medical diagnostic and drug screening. Here we demonstrate that cantilever arrays functionalized with different mannosides allow the real-time detection of several Escherichia coli strains in solution. Cantilever deflection is thereby dependent on the bacterial strain studied and the glycan used as the sensing molecule. The cantilevers exhibit specific and reproducible deflection with a sensitivity range over four orders of magnitude.
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