Journal
NANO LETTERS
Volume 11, Issue 10, Pages 4411-4414Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl2025882
Keywords
Liposomes; myocardial infarction; nanoparticles; targeting
Categories
Funding
- NIH [EB000244, EB006365, HL 086967, GM073626]
- American Heart Association
- Misrock Foundation
Ask authors/readers for more resources
We report a nanoparticulate system capable of targeting the heart after myocardial infarction (MI). Targeting is based on overexpression of angiotensin II type 1 (AT1) receptor in the infarcted heart. Liposomes 142 nm in diameter were conjugated with a ligand specific to AT1. The nanoparticles were able to specifically target cardiac cells in vitro, and in the infarcted heart after intravenous injection in vivo. This system may be useful for delivering therapeutic agents specifically to the infarcted heart.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
