Journal
NANO LETTERS
Volume 11, Issue 12, Pages 5344-5348Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl202877r
Keywords
Gold nanoparticle; surface-enhanced Raman scattering; plasmonics; Raman imaging; cellular transportation
Categories
Funding
- JST
- Osaka University Photonics Advanced Research Center
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Dynamic SERS imaging inside a living cell is demonstrated with the use of a gold nanoparticle, which travels through the intracellular space to probe local molecular information over time. Simultaneous tracking of particle motion and SERS spectroscopy allows us to detect intracellular molecules at 65 nm spatial resolution and 50 ms temporal resolution, providing molecular maps of organelle transport and lisosomal accumulation. Multiplex spectral and trajectory imaging will enable imaging of specific dynamic biological functions such as membrane protein diffusion, nuclear entry, and rearrangement of cellular cytoskeleton.
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