Journal
NANO LETTERS
Volume 11, Issue 3, Pages 1076-1081Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl103951e
Keywords
Nanowires; adhesion; drug delivery; hierarchical nanostructures
Categories
Funding
- NSF
- NIH [EB01166401]
- Rogers Foundation
- University of California
- Nanosys, Inc
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To circumvent the barriers encountered by macromolecules at the gastrointestinal mucosa, sufficient therapeutic macromolecules must be delivered in close proximity to cells.(1) Previously, we have shown that silicon nanowires penetrate the mucous layer and adhere directly to cells under high shear.(2) In this work, we characterize potential reservoirs and load macromolecules into interstitial space between nanowires. We show significant increases in loading capacity due to nanowires while retaining adhesion of loaded particles under high shear.
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