Journal
NANO LETTERS
Volume 11, Issue 2, Pages 772-780Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl103992v
Keywords
Gold nanorods; serum proteins; uptake and removal; intracellular localization; mitochondrion-targeted nanomaterials; tumor therapy
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Funding
- National Basic Research Program of China [2010CB934004, 2011CB933401]
- National Natural Science Foundation of China [31070854]
- Major National ST Program [2008ZX10001-010]
- Chinese Academy of Sciences [KJCX2-YW-M02]
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We have observed that Au nanorods (NRs) have distinct effects on cell viability via killing cancer cells while posing negligible impact on normal cells and mesenchymal stem cells. Obvious differences in cellular uptake, intracellular trafficking, and susceptibility of lysosome to Au NRs by different types of cells resulted in selective accumulation of Au NRs in the mitochondria of cancer cells. Their long-term retention decreased mitochondrial membrane potential and increased reactive oxygen species level that enhances the likelihood of cell death. These findings thus provide guidance for the design of organelle-targeted nanomaterials in tumor therapy.
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