Journal
NANO LETTERS
Volume 11, Issue 7, Pages 2796-2803Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl2011214
Keywords
Single-walled carbon nanotubes; lung; carcinogenesis; malignant transformation; apoptosis
Categories
Funding
- National Institute for Occupational Safety and Health
- National Institutes of Health [R01-HL095579]
- National Science Foundation [EPS-1003907]
- Office of Integrative Activities
- Office Of The Director [1003907] Funding Source: National Science Foundation
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Carcinogenicity of carbon nanotubes is a major concern but has not been well addressed due to the lack of experimental models. Here, we show that chronic exposure to single-walled carbon nanotubes causes malignant transformation of human lung epithelial cells. The transformed cells induce tumorigenesis in mice and exhibit an apoptosis resistant phenotype characteristic of cancer cells. This study provides new evidence for carbon nanotube-induced carcinogenesis and indicates the potential role of p53 in the process.
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