Journal
NANO LETTERS
Volume 11, Issue 9, Pages 3643-3648Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl201514a
Keywords
Scaffold; cardiomyocyte; conductive; Au nanoparticles; HEMA; connexin 43
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Funding
- Kavli Institute for Bionano Science and Technology at Harvard University
- National Science Foundation [DMR-0820484, ECS-0335765]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [820484] Funding Source: National Science Foundation
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Scaffolds that couple electrical and elastic properties may be valuable for cardiac cell function. However, existing conductive materials do not mimic physiological properties. We prepared and characterized a tunable, hybrid hydrogel scaffold based on Au nanoparticles homogeneously synthesized throughout a polymer templated gel. Conductive gels had Young's moduli more similar to myocardium relative to polyaniline and polypyrrole, by 1-4 orders of magnitude. Neonatal rat cardiomyocytes exhibited increased expression of connexin 43 on hybrid scaffolds relative to HEMA with or without electrical stimulation.
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