Journal
NANO LETTERS
Volume 11, Issue 3, Pages 1284-1288Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl104329y
Keywords
Pulsatile drug release; responsive membrane; electric stimulus; polypyrrole; anodic aluminum oxide membrane
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Funding
- National Research Foundation of Korea (NRF)
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We report on the fabrication of electrically responsive nanoporous membrane based on polypyrrole doped with dodecylbenzenesulfonate anion (PPy/DBS) that was electropolymerized on the upper part of anodized aluminum oxide membrane. The membrane has regular pore size and very high pore density. Utilizing a large volume change of PPy/DBS depending on electrochemical state, the pore size was acutated electrically. The actuation of the pores was experimentally confirmed by in situ atomic force microscopy and in situ flux measurement. We also demonstrated successfully pulsatile (or on-demand) drug release by using fluorescently labeled protein as a model drug. Because of a fast switching time (less than 10 s) and high flux of the drugs, this membrane could be used for emergency therapy of angina pectoris and migraine, which requires acute and on-demand drug delivery, and hormonerelated disease and metabolic syndrome.
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