Journal
NANO LETTERS
Volume 11, Issue 10, Pages 4037-4042Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl1036148
Keywords
Biosensor; optical resonator; rolled-up; microsyringe; nanomembrane; lab-in-a-tube
Categories
Funding
- Volkswagen Foundation [I/84 072]
- Multidisciplinary University Research Initiative (MURI)
- U.S. Air Force Office of Scientific Research (AFOSR) [FA9550-09-1-0550]
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We report a method for the precise capturing of embryonic fibroblast mouse cells into rolled-up microtube resonators. The microtubes contain a nanometer-sized gap in their wall which defines a new type of optofluidic sensor, i.e., a flexible split-wall microtube resonator sensor, employed as a label-free fully integrative detection tool for individual cells. The sensor action works through peak sharpening and spectral shifts of whispering gallery modes within the microresonators under light illumination.
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