Journal
NANO LETTERS
Volume 11, Issue 12, Pages 5391-5395Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl2030213
Keywords
Effective uptake; passive endocytosis; phospholipid membrane; nanoparticle shape; molecular dynamics
Categories
Funding
- Churchill College, Cambridge
- Linneaus Center of excellence Organizing Molecular Matter (OMM), Lund, Sweden
- ERC [227758]
- Royal Society of London
- European Research Council (ERC) [227758] Funding Source: European Research Council (ERC)
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Cellular uptake through endocytosis is crucial for drug delivery and nanomedicine. However, the conditions under which passive endocytosis (i.e., not ATP driven) takes place are not well understood. We report MD simulations of the passive uptake of ligand-coated nanoparticles with varying size, shape, coverage, and membrane-binding strength. We find that the efficiency of passive endocytosis is higher for spherocylindrical particles than for spheres and that endocytosis is suppressed for particles with sharp edges.
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