Journal
NANO LETTERS
Volume 12, Issue 1, Pages 512-517Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl204098n
Keywords
Nanopores; single molecules; DNA origami; self assembly; resistive pulse sensing; biosensing
Categories
Funding
- NanoDTC EPSRC at the University of Cambridge
- Deutsche Forschungsgemeinschaft (DFG) [LI1743/2-1]
- Nanoscience E+ initiative
- Nanosystems Initiative Munich
- Royal Society
- EPSRC [EP/H006672/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/H006672/1] Funding Source: researchfish
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We demonstrate the assembly of functional hybrid nanopores for single molecule sensing by inserting DNA origami structures into solid-state nanopores. In our experiments, single artificial nanopores based on DNA origami are repeatedly inserted in and ejected from solid-state nanopores with diameters around 15 nm. We show that these hybrid nanopores can be employed for the detection of A-DNA molecules. Our approach paves the way for future development of adaptable single-molecule nanopore sensors based on the combination of solid-state nanopores and DNA self-assembly.
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