Journal
NANO LETTERS
Volume 11, Issue 9, Pages 3946-3950Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl202220q
Keywords
Peptide amphiphile; dendrimer; templating; protein analog; self-assembly; biomaterials
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Funding
- MRSEC of the NSF [DMR05-20415]
- National Institutes of Health [NIH1U01 HL080718, HHSN268201000046C, NIH 1U54 CA119335]
- UC Berkeley College of Engineering
- DOE Office of Science
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Self-assembling peptide amphiphiles (PAs) have been extensively used in the development of novel biomaterials. Because of their propensity to form cylindrical micelles, their use is limited in applications where small spherical micelles are desired. Here we present a platform method for controlling the self-assembly of biofunctional PM into spherical SO nm particles using dendrimers as shape-directing scaffolds. This templating approach results in biocompatible, stable protein-like assemblies displaying peptides with native secondary structure and biofunctionality.
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