Journal
NANO LETTERS
Volume 11, Issue 4, Pages 1469-1476Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl104079r
Keywords
Integrin; focal adhesion; ECM; micronanostructures; biointerfaces; single cell force spectroscopy (SCFS)
Categories
Funding
- National Institutes of Health through the NIH Roadmap for Medical Research [PN2 EY016586]
- European Union [NMP4-LA-2009-229289, NMP3-SL-2009-229294]
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alpha(v)beta(3) integrin-mediated cell adhesion is crucially influenced by how far ligands are spaced apart. To evaluate the impact of local ligand density versus global ligand density of a given surface, we used synthetic micronanostructured cell environments with user-defined ligand spacing and patterns to investigate cellular adhesion. The development of stable focal adhesions, their number, and size as well as the cellular adhesion strength proved to be influenced by local more than global ligand density.
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