Journal
NANO LETTERS
Volume 11, Issue 7, Pages 2901-2904Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl201368w
Keywords
SP1; nanochannel; lipid membrane; neurons; neuroelectronic interface
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The assembly of functional junction between nerve cells and electronic sensing pads is a critical problem in the construction of effective neuroelectronic hybrid systems. Here, we demonstrate for the first time that the ringlike Stable Protein 1 (Sp1) and its derivatives can be used to generate hydrophilic nanochannels in the plasma membrane of living cells. Since SP1-derivatives can be linked to both the plasma membrane, gold or silicon surfaces, they may serve to ohmically link between cells interior and electronic sensing devices.
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