Journal
NANO LETTERS
Volume 11, Issue 4, Pages 1664-1670Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl2001499
Keywords
Stealth liposorne; superparamagnetic iron oxide nanopartide; triggered release; drug delivery vehicle; nanoreactor; palmityl-nitroDOPA
Categories
Funding
- COST Action [D43]
- ETH Zurich
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The ideal nanoscale drug delivery vehicle allows control over the released dose in space and time We demonstrate that this can be achieved by stealth liposomes comprising self assembled superpararnagnetic iron oxide nanoparticles (NPs) individually stabilized with palmityl-nitroDOPA incorporated in the lipid membrane. Alternating magnetic fields were used to control timing and dose of repeatedly released cargo from such vesicles by locally heating the membrane, which changed its permeability without major effects on the environment.
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