Journal
NANO LETTERS
Volume 11, Issue 8, Pages 3174-3183Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl201391e
Keywords
C. elegans; quantum dots; biodistribution; chemical speciation; in vivo imaging; reproductive toxicity
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Funding
- National Basic Research Program of China (973 Program) [2011CB9334001, 2010CB934004, 2009CB930401]
- National Natural Science Foundation of China [10975040, 20931160430, 31070854]
- National Natural Science Foundation for Distinguished Youth Scholars of China [21025310]
- CAS
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We evaluated the in vivo fate and physiological behavior of quantum dots (QDs) in Caenorhabditis elegans by GFP transfection, fluorescent imaging, synchrotron radiation based elemental imaging, and speciation techniques. The in situ metabolism and degradation of QDs in the alimentary system and long-term toxicity on reproduction are fully assessed. This work highlights the utility of the C. elegans model as a multi-flexible platform to allow noninvasively imaging and monitoring in vivo consequences of engineered nanomaterials.
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