Journal
NANO LETTERS
Volume 11, Issue 7, Pages 2997-3002Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl201603a
Keywords
Structural DNA nanotechnology; self-assembly; DNA origami; scale up
Categories
Funding
- ONR
- NSF
- ARO
- DOE
- NIH
- Sloan Research Foundation
- U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-SC0001016]
- NSFC [21028005]
- Wong Kwan Cheng education foundation
- Division of Computing and Communication Foundations
- Direct For Computer & Info Scie & Enginr [0829685] Funding Source: National Science Foundation
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Structural DNA nanotechnology utilizes DNA molecules as programmable information-coding polymers to create higher order structures at the nanometer scale. An important milestone in structural DNA nanotechnology was the development of scaffolded DNA origami in which a long single-stranded viral genome (scaffold strand) is folded into arbitrary shapes by hundreds of short synthetic oligonucleotides (staple strands). The achievable dimensions of the DNA origami tile units are currently limited by the length of the scaffold strand. Here we demonstrate a strategy referred to as superorigami or origami of origami to scale up DNA origami technology. First, this method uses a collection of bridge strands to prefold a single-stranded DNA scaffold into a loose framework. Subsequently, preformed individual DNA origami tiles are directed onto the loose framework so that each origami tile serves as a large staple. Using this strategy, we demonstrate the ability to organize DNA origami nanostructures into larger spatially addressable architectures.
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