Journal
NANO LETTERS
Volume 10, Issue 6, Pages 2237-2244Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl1012147
Keywords
Solid-state nanopore; single-molecule; optical detection; circular DNA conversion
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Funding
- NIH [HG-004128]
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We demonstrate the feasibility of a nanopore based single-molecule DNA sequencing method, which employs multicolor readout. Target DNA is converted according to a binary code, which is recognized by molecular beacons with two types of fluorophores. Solid-state nanopores are then used to sequentially strip off the beacons, leading to a series of detectable photon bursts, at high speed. We show that signals from multiple nanopores can be detected simultaneously, allowing straightforward parallelization to large nanopore arrays.
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