Journal
NANO LETTERS
Volume 10, Issue 1, Pages 59-63Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl902830x
Keywords
Gold nanorods; human immune cells; nanoparticle clearance
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It has recently been discovered that human immune cells, especially neutrophil granulocytes. form neutrophil extracellular traps (NETS) that abolish pathogens. Our study provides evidence that extracellular traps formed by neutrophils, monocytes and macrophages act as physical barriers for nanoparticles, thus presenting a new nanomaterial clearance mechanism of the human immune system. While particle shape is of minor importance, positive charges significantly enhance particle trapping.
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