Journal
NANO LETTERS
Volume 10, Issue 9, Pages 3237-3242Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl9035934
Keywords
Nucleic acid; sequencing; graphene; electrical current; conductance spectroscopy; density functional theory
Categories
Funding
- NSF [CHE-0701517]
- ACS [PRF 41436-AC6]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [GRANTS:13728193, 1050405] Funding Source: National Science Foundation
Ask authors/readers for more resources
We report an ab initio density functional theory study of the interaction of four nucleobases, cytosine, thymine, adenine, and guanine, with a novel graphene nanopore device for detecting the base sequence of a single-stranded nucleic acid (ssDNA or RNA). The nucleobases were inserted into a pore in a graphene nanoribbon, and the electrical current and conductance spectra were calculated as functions of voltage applied across the nanoribbon. The conductance spectra and charge densities were analyzed in the presence of each nucleobase in the graphene nanopore. The results indicate that due to significant differences in the conductance spectra the proposed device has adequate sensitivity to discriminate between different nucleotides. Moreover, we show that the nucleotide conductance spectrum is affected little by its orientation inside the graphene nanopore. The proposed technique may be extremely useful for real applications in developing ultrafast, low-cost DNA sequencing methods.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available