Journal
NANO LETTERS
Volume 10, Issue 7, Pages 2318-2322Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl101019s
Keywords
anti-CD4 antibodies; biologically targeted in vivo imaging; contrast agent; gold nanoparticles; X-ray computed tomography
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Funding
- National Science Foundation/EPSCoR [0132384]
- EPSCoR
- Office Of The Director [0132384] Funding Source: National Science Foundation
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Antibody-conjugated gold nanoparticles have been applied as a biologically targeted contrast agent in live mice for one of the most widely used medical imaging methods, X-ray computed tomography Such nanoprobes directed toward the CD4 receptor lead to distinctly enhanced X-ray contrast of peripheral lymph nodes This study demonstrates the general feasibility of biologically specific X-ray imaging in living animals and discusses basic requirements for the use of nanoparticles as a targeted X-ray contrast agent
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