Journal
NANO LETTERS
Volume 10, Issue 7, Pages 2543-2548Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl101140t
Keywords
Gold nanoparticles; surface properties; cancer; membrane potential; calcium; apoptosis
Categories
Funding
- NIH [CA135011, CA136494, HL090595, GM077173, HL088029]
- UTMD-1
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Herein, we demonstrate that the surface charge of gold nanoparticles (AuNPs) plays a critical role in modulating membrane potential of different malignant and nonmalignant cell types and subsequent downstream intracellular events The findings presented here describe a novel mechanism for cell-nanoparticle interactions and AuNP uptake modulation of membrane potential and its effect on intracellular events. These studies will help understand the biology of cell-nanoparticle interactions and facilitate the engineering of nanoparticles for specific intracellular targets
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