Journal
NANO LETTERS
Volume 10, Issue 3, Pages 1093-1097Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl1002526
Keywords
Viral nanoparticle; chemical ligation; cell imaging; tumor targeting; VEGFR-1
Categories
Funding
- NIH [P01 HD09402, R01 GM059380, R01 HL 068648, R01 CA112075, K99 EB009105]
- CIHR [MOP-84535]
- American Heart Association Postdoctoral Fellowship
- AmfAR
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Multivalent nanoparticle platforms are attractive for biomedical applications because of their improved target specificity, sensitivity, and solubility. However, their controlled assembly remains a considerable challenge, An efficient hydrazone ligation chemistry was applied to the assembly of Cowpea mosaic virus (CPMV) nanoparticles with individually tunable levels of a VEGFR-I ligand and a fluorescent PEGylated peptide. The nanoparticles recognized VEGFR-I on endothelial cell lines and VEGFR I-expressing tumor xenografts in mice, validating targeted CPMV as a nanoparticle platform in vivo.
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