Journal
NANO LETTERS
Volume 10, Issue 3, Pages 1070-1075Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl1001185
Keywords
DNA sequencing; electron tunneling; DNA nucleosides; hydrogen bonding; molecular recognition
Categories
Funding
- National Human Genome Research Institute [HG004378]
Ask authors/readers for more resources
Nucleosides diffusing through a 2 nm electron-tunneling junction generate current spikes of sub-millisecond duration with a broad distribution of peak currents. This distribution narrows 10-fold when one of the electrodes is functionalized with a reagent that traps nucleosides in a specific orientation with hydrogen bonds. Functionalizing the second electrode reduces contact resistance to the nucleosides, allowing them to be identified via their peak currents according to deoxyadenosine > deoxycytidine > deoxyguanosine > thymidine, in agreement with the order predicted by a density functional calculation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available